Must know ‘New Drugs’ for AIIMS-PG by Dr. Gobind Rai Garg

Jun 05 , 2020

Pharmacology expert, Dr. Gobind Rai Garg has come up with a list of important ‘New Drugs’. This list has been compiled keeping in mind the upcoming AIIMS-PG exam.

After going through this blog, you’ll be well versed to answer any question related to this topic in the exam.

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IMPORTANT DRUGS FOR AIIMS-PG

The table includes the name of the drug, mechanism, route, and indication.

Drug	Mechanism	Route	Indication
Andexanet alpha	Bind to Factor Xa inhibitors	Intravenous	To reverse overdose of rivaroxaban and apixaban
Brexanolone	GABA-A modulator	Intravenous	Post partum depression
Baloxavirmarboxil	Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymerase	Oral	Single dose treatment of Acute uncomplicated influenza
Elagolix	GnRH antagonist	Oral	Pain associated with endometriosis
Esketamine	Non-competitive NMDA antagonist	Intranasal	Treatment resistant depression
Ibalizumab	MAb against CD4	Intravenous	HIV
Pretomanid	Inhibit mycolic acid synthesis	Oral	For XDR and MDR TB (in combination with bedaquiline and linezolid)
Pitolisant	H3 antagonist/inverse agonist	Oral	Narcolepsy
Tenapanor	Sodium hydrogen exchanger-3 (NHE-3) inhibitor	Oral	IBS with constipation
Tafenoquine	Free radical mediated killing of hypnozoites	Oral	Single dose radical cure of P. vivax malaria
Lemborexant	Dual Orexin Antagonist (DORA)- binds to both the orexin receptors OX1R and OX2R	Oral	Insomnia
Remdesivir	Remdesivir triphosphate inhibits viral RNA dependent RNA polymerase	Intravenous	Coronavirus disease 2019 (COVID-19)
Ubrogepant	CGRP receptor antagonist	Oral	Acute treatment of migraine with or without aura
Rimegepant	CGRP receptor antagonist	Oral	Acute treatment of migraine with or without aura
Lasmiditan	5HT1F agonist	Oral	Acute treatment of migraine with or without aura
Erenumab	Monoclonal antibody against CGRP receptor	SC	Migraine prophylaxis
Galcanezumab	Monoclonal antibody against CGRP receptor	SC	Migraine prophylaxis
Fremanezumab	Binds to CGRP ligand blocking its binding to CGRP receptor.	SC	Migraine prophylaxis
Eptinezumab	Binds to CGRP ligand blocking its binding to CGRP receptor.	Intravenous	Migraine prophylaxis
Romosozumab	MAB against sclerostin	SC	Osteoporosis in postmenopausal women at high risk of fracture